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《分子药理学杂志》

期刊分类:药学

创刊年份:2001

国际刊号:ISSN 0026-895X

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  • 杂志简介

      Our mission is to provide A window to the free accessible biomedical resources for your study and practice:Monthly issues present original applications of biochemistry, biophysics, genetics, and molecular biology juxtaposed with innovative pharmacologic research to elucidate basic problems i...

    2008年3期

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  • Combined Effects of Sulindac and Suberoylanilide Hydroxamic Acid on Apoptosis Induction in Human Lung Cancer Cells
  • Sung-Keum Seo,Hyeon-Ok Jin,Hyung-Chahn Lee,Sang-Hyeok..
  • Analysis of Promoter Regions Regulating Basal and Interleukin-4-Inducible Expression of the Human CB1 Receptor Gene in T Lymphocytes
  • Christine Börner,Andrea Bedini,Volker Höllt, andJürgen..
  • Inhibition of Sodium Channel Gating by Trapping the Domain II Voltage Sensor with Protoxin II
  • Stanislav Sokolov,Richard L. Kraus,Todd Scheuer, andWilliam..
  • Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes
  • Robert A. B. van Waterschoot,Antonius E. van..
  • Progesterone Acts via Progesterone Receptors A and B to Regulate Breast Cancer Resistance Protein Expression
  • Mary Vore, andMarkos Leggas
  • Distinctions between Dopamine Transporter Antagonists Could be Just around the Bend
  • L. Keith Henry, andRandy D. Blakely
  • Ginsenoside Rg3 Inhibits Human Kv1.4 Channel Currents by Interacting with the Lys531 Residue
  • Jun-Ho Lee,Byung-Hwan Lee,Sun-Hye Choi,In-Soo Yoon,Mi Kyung..
  • Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcino..
  • Sufi Mary Thomas,Michelene Jeter Ogagan,Maria L...
  • 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic Acid (PD-307243) Causes Instantaneous Current through Human Ether-a-go-go-Related Gene Potas..
  • Earl Gordon,Irina M. Lozinskaya,Zuojun Lin,Simon F...
  • Activation of the Dual-Leucine-Zipper-Bearing Kinase and Induction of β-Cell Apoptosis by the Immunosuppressive Drug Cyclosporin A
  • Silke Plaumann,Roland Blume,Svenja Börchers,Hans Jürgen..
  • Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of Human Dehydroepiandrosterone Sulfotransferase (SULT2A1)
  • Lu-Yi Lu,Yin-Cheng Hsieh,Ming-Yih Liu,Yih-Hung..
  • Potent Inhibition of Human Apurinic/Apyrimidinic Endonuclease 1 by Arylstibonic Acids
  • Lauren A. Seiple,John H. Cardellina, II,Rhone Akee,..
  • Caveolin Regulates Kv1.5 Trafficking to Cholesterol-Rich Membrane Microdomains
  • Dyke P. McEwen,Qiuju Li,Sajida Jackson,Paul M. Jenkins,..
  • A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase II Inhibitors
  • Hong Liang,Xing Wu,Jack C. Yalowich, andBrian B. Hasinoff
  • Derlin-1 and p97/Valosin-Containing Protein Mediate the Endoplasmic Reticulum-Associated Degradation of Human V2 Vasopressin Receptors
  • Isabel Schwieger,Katja Lautz,Eberhard Krause,Walter..
  • Antitumorigenic Effects of Peroxisome Proliferator-Activated Receptor- in Non-Small-Cell Lung Cancer Cells Are Mediated by Suppression of Cyclooxygenase-2 via Inhib..
  • Yvette Bren-Mattison1,Amy M. Meyer,Vicki Van Putten,Howard..
  • Cell-Based and Biochemical Structure-Activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin
  • Brianne S. Raccor,Andreas Vogt,Rachel P. Sikorski,Charitha..
  • The Two Isoforms of the Na+/Ca2+ Exchanger, NCX1 and NCX3, Constitute Novel Additional Targets for the Prosurvival Action of Akt/Protein Kinase B Pathway
  • Luigi Formisano,Mariangela Saggese,Agnese Secondo,Rossana..
  • Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis
  • Juliann G. Kiang,Sandeep Krishnan,Xinyue Lu, andYansong Li
  • Inverse Agonist and Neutral Antagonist Actions of Antidepressants at Recombinant and Native 5-Hydroxytryptamine2C Receptors: Differential Modulation of Cell Surface..
  • Benjamin Chanrion,Clotilde Mannoury la Cour,Sophie..
  • Small-Molecule Screen Identifies Inhibitors of a Human Intestinal Calcium-Activated Chloride Channel
  • Ricardo De La Fuente,Wan Namkung,Aaron Mills, andA. S...
  • Dioxin-Mediated Up-Regulation of Aryl Hydrocarbon Receptor Target Genes Is Dependent on the Calcium/Calmodulin/CaMKI Pathway
  • Patricia Monteiro,David Gilot,Eric Le Ferrec,Claudine..
  • Interferon β Augments Tuberous Sclerosis Complex 2 (TSC2)-Dependent Inhibition of TSC2-Null ELT3 and Human Lymphangioleiomyomatosis-Derived Cell Proliferation
  • Elena A. Goncharova,Dmitry A. Goncharov,Amelia..
  • Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists
  • Rama Kondru,Jun Zhang,Changhua Ji,Tara Mirzadegan,David..
  • Activity and Subcellular Trafficking of the Sodium-Coupled Choline Transporter CHT Is Regulated Acutely by Peroxynitrite
  • Metta Pinthong,Stefanie A. G. Black,Fabiola M...
  • Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors
  • Claus J. Loland,Rajeev I. Desai,Mu-Fa Zou,Jianjing..
  • The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine
  • Yong-Wei Zhang,Zhi-Xiang Zhang,Ze-Hong Miao, andJian Ding
  • Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution and T..
  • X. Xu,R. Sutak, andD. R. Richardson
  • Progesterone Receptor (PR) Isoforms PRA and PRB Differentially Regulate Expression of the Breast Cancer Resistance Protein in Human Placental Choriocarcinoma BeWo C..
  • Honggang Wang,Eun-Woo Lee,Lin Zhou,Peter C. K...
  • An Intracellular Allosteric Site for a Specific Class of Antagonists of the CC Chemokine G Protein-Coupled Receptors CCR4 and CCR5
  • Glen Andrews,Carolyn Jones, andKeith A. Wreggett
  • Plasticity of Adenylyl Cyclase-Related Signaling Sequelae after Long-Term Morphine Treatment
  • Michael Shy,Sumita Chakrabarti, andAlan R. Gintzler
  • Lipid Composition Alters Drug Action at the Nicotinic Acetylcholine Receptor
  • John E. Baenziger,Stephen E. Ryan,Michael M. Goodreid,Ngoc..
  • Identification of Oxysterol 7-Hydroxylase (Cyp7b1) as a Novel Retinoid-Related Orphan Receptor (ROR) (NR1F1) Target Gene and a Functional Cross-Talk between ROR an..
  • Taira Wada,Hong Soon Kang,Martin Angers,Haibiao Gong,Shikha..
  • Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes
  • Andria L. Del Tredici,Carsten B. Andersen,Erika A...
  • N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator of Gro..
  • Yelin Chen,Cyril Goudet,Jean-Philippe Pin, andP. Jeffrey Conn
  • A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression
  • Rajesh R. Nair,Hector Avila,Xujun Ma,Zhengxin Wang,Michelle..
  • Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by P..
  • Radu Vasilcanu,Daiana Vasilcanu,Bita Sehat,Shucheng..
  • State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+ Channel Isoforms by Ranolazine
  • Ging Kuo Wang,Joanna Calderon, andSho-Ya Wang
  • The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Fetal Distribution of Glyburide in the Pregnant Mouse: An Obstetric-Fetal Pharmacology Research Unit Netwo..
  • Lin Zhou,Suresh Babu Naraharisetti,Honggang Wang,Jashvant..
  • Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the 4β3 GABAA Receptor
  • Nelson P. Barrera,Jill Betts,Haitao You,Robert M...
  • Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor by Dehydroepiandrosterone and Other Peroxisome Proli..
  • Viola Tamasi,Kristy K. Michael Miller,Sharon L. Ripp,Ermin..
  • N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
  • A. D. Wickenden,J. L. Krajewski,B. London,P. K. Wagoner,W...
  • A New Mechanism of 6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one Dihydrochloride (TAS-103) Action Discovered by Target Screening with D..
  • Makoto Yoshida,Yasuaki Kabe,Tadashi Wada,Akira Asai,..
  • Direct Role of Streptozotocin in Inducing Thermal Hyperalgesia by Enhanced Expression of Transient Receptor Potential Vanilloid 1 in Sensory Neurons
  • Reddy M. Pabbidi,De-Shou Cao,Arti Parihar,Mary E. Pauza,..
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