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肺泡内液体清除与肺水肿的研究进展

首席医学网      2014年11月02日 23:11:44 Sunday  
 
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作者:石伟, 张中军, 陶明哲    作者单位:518000 广东深圳,暨南大学第二临床学院 深圳市人民医院麻醉科

【摘要】  肺水肿是急性肺损伤(ALI)病理进程中的中心环节,与肺泡毛细血管通透性增加和肺泡内液体清除减少有关。以往对肺泡毛细血管通透性导致的肺水肿研究较多,而对肺泡内液体清除在肺水肿形成中的作用关注不足。肺泡内液体清除受水通道蛋白、钠离子通道、钠钾ATP酶的影响。认识肺泡内液体清除机制有望能为临床医师治疗ALI提供参考。

【关键词】  肺水肿; 水孔蛋白质类; 钠通道; 钠钾交换ATP酶; 肺泡内液体清除

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